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KMID : 0931320150150040243
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대한상부위장관.헬리코박터학회지
2015 Volume.15 No. 4 p.243 ~ p.248
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Helicobacter pylori Infection and Intestinal Metaplasia among Healthy Adolescents
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:Park Ji-Sook
:Rhie Kyu-Yol/:Seo Ji-Hyun/:Ryu Eo-Young/:Kim Hyun-Jin/:Kim Hong-Jun/:Lim Jae-Young/:Woo Hyang-Ok/:Baik Seung-Chul/:Lee Woo-Kon/:Cho Myung-Je/:Rhee Kwang-Ho/:Ko Gyung-Hyuck/:Youn Hee-Shang
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Abstract
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Background/Aims: The purpose of our study was to investigate the change in incidence of intestinal metaplasia (IM) in healthy, young adults over 10 years.
Materials and Methods: Urease test and histopathology by endoscopic biopsies were performed from volunteers between 1995 and 2005. Histopathological grade was assessed using the updated Sydney System.
Results: In total, 714 subjects with a median age of 22.4 years were enrolled. Helicobacter pylori was observed at the antrum and body in 44.5% and 35.1%, respectively. IM limited to the antrum was present in 1.1% of the subjects. The degree of IM correlated negatively with age (P=0.04) but there was no correlation with H. pylori levels or the degree of chronic or active gastritis. Compared to the beginning of the study period, the positivity rate at the end of the study period droped to 45%. IM incidence did not change over the 11-year study period, whereas H. pylori-positivity and the frequency of chronic and active gastritis in the antrum and body dropped significantly over this period (P＜0.05).
Conclusions: This result suggests that other factors, besides chronic H. pylori infection or degree of gastritis, may contribute to the progression of atrophy to IM in healthy, young adults.
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KEYWORD
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Helicobacter pylori, Intestinal metaplasia
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